基本信息
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 姓名:
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万虎 |
出生年月: |
1984.10 |
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性别: |
男 |
硕/博导： |
博导 |
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民族: |
汉族 |
开设课程： |
农药学概论、植物化学保护学、农药学研究进展 |
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职称: |
教授 |
研究方向： |
农药毒理学、核酸农药创制 |
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学位: |
理学博士 |
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联系方式
电子邮件：huwan@mail.hzau.edu.cn
办公地址：三综B711 |
个人简介
万虎，男，1984年10月29日出生，江西九江人，博士，教授，博士研究生导师。主要从事农药毒理及核酸农药创制等研究。
（一）学习经历
2002/09-2006/06 新葡萄官网登录入口新葡萄官网登录入口获农学学士学位
2006/09-2008/12 新葡萄官网登录入口新葡萄官网登录入口获农学硕士学位
2009/03-2013/02 韩国东亚大学生命资源科学学院获理学博士学位
（二）工作经历
2013/06 - 2017/12 新葡萄官网登录入口新葡萄官网登录入口植物保护系 讲 师
2018/01 - 至今 新葡萄官网登录入口新葡萄官网登录入口植物保护系 副教授
（三）主要学术兼职
湖北省植物保护学会第十一届理事会理事
中国植物保护学会第七届青年工作委员会委员
科研项目
1. 国家自然科学基金，共生菌Wolbachia调控褐飞虱对氟啶虫胺腈抗性的分子机制研究，项目年限：2021-2024，（主持） 2. 湖北省重点研发计划，褐飞虱P450基因靶向性RNAi纳米农药创制，项目年限：2021-2023，（主持） 3. 湖北省自然科学基金，褐飞虱共生菌协同宿主解毒代谢机制研究，项目年限：2019-2020，（主持） 4. 国家自然科学基金，褐飞虱共生菌调控宿主解毒代谢基因细胞色素P450表达的机制研究，项目年限：2019-2022，（主持） 5. 新葡萄官网登录入口校自主创新基金，褐飞虱共生菌Wolbachia介导宿主解毒代谢机制研究，项目年限：2018-2020，（主持） 6. 湖北省青年英才开发计划，项目年限：2017-2019，（主持） 7. 湖北省重大科技创新计划，双酰胺类杀虫剂缓释剂的制备及生物活性研究，项目年限：2016-2019，（参与） 8. 国家重点研发计划，水稻化学农药协同增效技术与产品研发，项目年限：2016-2020，（子课题主持） 9. 国家自然科学基金，褐飞虱对氟啶虫胺腈早期抗性进化机理研究，项目年限：2016-2018，（主持） 10. 新葡萄官网登录入口自主创新基金，斜纹夜蛾过氧化物还原酶SlPrx5分子克隆及功能分析，项目年限：2014-2015，（主持） 11. 新进博士科研启动专项，甜菜夜蛾谷胱甘肽转移酶的分子特性研究，项目年限：2013-2014，（主持）
教学研究与教学改革 1. 2020年学院教改项目：新葡萄官网登录入口“课程思政”《农药学概论》示范建设项目（主持） 2. 2019年校级教改项目：新葡萄官网登录入口全英文课程《农药学研究进展》建设教改项目（主持） 3. 2018年校级教改项目：新葡萄官网登录入口第六批精品课程《植物化学保护学》在线开放课程建设（参与） 4. 2018年校级教改项目：新葡萄官网登录入口“思政课程”与“课程思政”《植物化学保护学》示范建设项目（参与） |
发明专利及获奖情况
发明专利： 1. 何顺，李建洪，万虎，马洪菊，游红，张小磊，高云昊，沙黑拉什·拉马赞. 一种纳米二氧化硅接枝有机功能高分子有机磷杀虫剂缓释剂及其制备方法，专利号：ZL 201610191276.1 2. 何顺，李建洪，万虎，马洪菊，高云昊，沙黑拉什·拉马赞，张小磊. 纳米二氧化硅接枝有机功能高分子大环内酯类杀虫剂缓释剂及其制备方法，专利号：ZL 201610191303.5 3. 何顺，李建洪，万虎，游红，高云昊，张小磊，廖逊. 一种纳米二氧化硅接枝有机功能高分子双酰胺类杀虫剂缓释剂及其制备方法，专利号：ZL 201610192026.X 4. 万虎，韩宁宁，李建洪，陈子姝，黄国华. 快速测定囊泡病毒滴度的方法，专利号：ZL 201610522012.X 5. 朱福兴，马洪菊，万虎，何顺，马伟华，杨中华. 一种复配杀菌剂及制备方法，专利号：ZL 201610807377.7 6. 万虎，李建洪，高娃，游红.大腹园蛛丝氨酸蛋白酶抑制剂AvSPI基因及其编码蛋白和应用，专利号：ZL 2013 1 0695392.3 主要奖励： 1. 2020年度新葡萄官网登录入口优秀班主任 2. 2019年度新葡萄官网登录入口优秀硕士学位论文指导教师 3. 2019年度新葡萄官网登录入口“研究生就业工作贡献奖” 4. 2016年度“湖北省青年英才开发计划” 5. 湖北省第十一届“挑战杯”大学生课外学术科技作品竞赛二等奖指导教师 6. 2016年度新葡萄官网登录入口教学质量优秀三等奖 7. 2015年度新葡萄官网登录入口教学质量优秀奖 8. 2014年度湖北省第十五届自然科学优秀学术论文三等奖 9. 2014北京GRC筹备和组织工作特别嘉奖 10. 第一届赵善欢奖学奖教基金优秀论文奖，2014，广州，中国
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发表的论文及著作（*表示通讯作者，#表示共同作者）：
学术论文
1. Ren, Z., Zhang, Y., Cai, T., Mao, K., Xu, Y., Li, C., He, S., Li, J., Wan, H.*, 2021. Dynamics of Microbial Communities across the Life Stages of Nilaparvata lugens (Stål). Microbiol Ecol. In Press.
2. Zhang, Y., Cai, T., Ren, Z., Liu, Y., Yuan, M., Cai, Y., Yu, C., Shu, R., He, S., Li, J., Wong, A.C.N.*, Wan, H.*, 2021. Decline in symbiont-dependent host detoxification metabolism contributes to increased insecticide susceptibility of insects under high temperature. The ISME J. In Press.
3. Zhang, Y. #, Liu, C. #, Jin, R., Wang, Y., Cai, T., Ren, Z., Ma, K., He, S., Lee, K.S., Jin, B.R., Li, J., Wan, H.*, 2021. Dual oxidase-dependent reactive oxygen species are involved in the regulation of UGT overexpression-mediated clothianidin resistance in the brown planthopper, Nilaparvata lugens. Pest Manage. Sci. 77, 4159-4167.
4. Tang, T. #, Zhang, Y. #, Cai, T., Deng, X., Liu, C., Li, J., He, S., Li, J., Wan, H.*, 2021. Antibiotics increased host insecticide susceptibility via collapsed bacterial symbionts reducing detoxification metabolism in the brown planthopper, Nilaparvata lugens. J. Pest. Sci. 94, 757-767.
5. Mao, K., Ren, Z., Li, W., Cai, T., Qin, X., Wan, H., Jin, B.R., He, S.*, Li, J.*, 2021. Carboxylesterase genes in nitenpyram-resistant brown planthoppers, Nilaparvata lugens. Insect Sci. 28, 1049-1060.
6. Mao, K. #, Ren, Z. #, Li, W., Liu, C., Xu, P., He, S., Li, J., Wan, H.*, 2021. An insecticide resistance diagnostic kit for whitebacked planthopper Sogatella furcifera (Horvath). J. Pest. Sci. 94, 531-540.
7. Cai, T., Zhang, Y., Liu, Y., Deng, X., He, S., Li, J., Wan, H.*, 2021. Wolbachia enhances expression of NlCYP4CE1 in Nilaparvata lugens in response to imidacloprid stress. Insect Sci. 28, 355-362.
8. Gao, Y. #, Xiao Y. #, Mao, K., Qin, X., Zhang, Y., Li, D., Zhang, Y., Li, J., Wan, H.*, He, S.*, 2020. Thermoresponsive polymer-encapsulated hollow mesoporous silica nanoparticles and their application in insecticide delivery. Chem. Eng. J. 383, 123169.
9. 廖逊，万虎，李建洪*，2019. 褐飞虱对杀虫剂抗性研究进展. 农药学学报. 21, 718-728.
10. 张云骅，李建洪，万虎*，2019. 昆虫共生菌与宿主的解毒代谢关系研究进展. 农药学学报. 21, 729-735.
11. Mao, K., Li, W., Liao, X., Liu, C., Qin, Y., Ren, Z., Qin, X., Wan, H., Sheng, F.*, Li, J.*, 2019. Dynamics of Insecticide Resistance in Different Geographical Populations of Chilo suppressalis (Lepidoptera: Crambidae) in China 2016-2018. J. Econ. Entomol. 112, 1866-1874.
12. Li, D. #, Zhang, Y. #, Li, W., Tang, T., Wan, H., You, H. *, Li, J. *, 2019. Fitness and evolution of insecticide resistance associated with gut symbionts in metaflumizone-resistant Plutella xylostella. Crop Prot. 124, 104869.
13. Liao, X., Mao, K., Ali, E., Jin, R., Li, Z., Li, W., Li, J., Wan, H.*, 2019. Inheritance and fitness costs of sulfoxaflor resistance in Nilaparvata lugens (Stål). Pest Manage. Sci. 75, 2981-2988.
14. Mao, K., Zhang, X., Ali, E., Liao, X., Jin, R., Ren, Z., Wan, H., Li, J.*, 2019. Characterization of nitenpyram resistance in Nilaparvata lugens (Stål). Pestic. Biochem. Physiol. 157, 26-30.
15. Mao, K. #, Jin, R. #, Li, W., Ren, Z., Qin, X., He, S., Li, J., Wan, H.*, 2019. The influence of temperature on the toxicity of insecticides to Nilaparvata lugens (Stål). Pestic. Biochem. Physiol. 156, 80-86.
16. 徐鹏飞，康廷浩，张 园，秦雪莹，何 顺，李建洪，万 虎*，2019. 卵磷脂桶混助剂的特性及其在防治稻飞虱中对氟啶虫胺腈的协同增效作用. 农药学学报. 21, 227-232.
17. Jin, R., Mao, K., Liao, X., Xu, P., Li, Z., Ali, E., Wan, H., Li, J.*, 2019. Overexpression of CYP6ER1 associated with clothianidin resistance in Nilaparvata lugens (Stål). Pestic. Biochem. Physiol. 154, 39-45.
18. Liao, X., Jin, R., Zhang, X., Ali, E., Mao, K., Xu, P., Li, J., Wan, H.*, 2019. Characterization of sulfoxaflor resistance in the brown planthopper, Nilaparvata lugens (Stål). Pest Manage. Sci. 75, 1646-1654.
19. Liao, X., Ali, E., Li, W., He, B., Gong, P., Xu, P., Li, J., Wan, H.*, 2019. Sublethal effects of sulfoxaflor on the development and reproduction of the brown planthopper, Nilaparvata lugens (Stål). Crop Prot. 118, 6-14.
20. Xu, P., Shu, R., Gong, P., Li, W., Wan, H., Li, J.*, 2019. Sublethal and transgenerational effects of triflumezopyrim on the biological traits of the brown planthopper, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae). Crop Prot. 117, 63-68.
21. Zhang, Y., Tang, T., Li, W., Cai, T., Li, J., Wan, H.*, 2018. Functional profiling of the gut microbiomes in two different populations of the brown planthopper, Nilaparvata lugens. J. Asia-Pac. Entomol. 21, 1309-1314.
22. Han, N., Chen, Z., Wan, H., Huang, G., Li, J.*, Jin, R.*, 2018. A rapid method for titration of ascovirus infectivity. J. Virol. Methods 255, 101-106.
23. Zhang, X., Mao, K., Liao, X., He, B., Jin, R., Tang, T., Wan, H., Li, J.*, 2018. Fitness cost of nitenpyram resistance in the brown planthopper Nilaparvata lugens. J. Pest. Sci. 91, 1145-1151.
24. Ali, E., Liao, X., Yang, P., Mao, K., Zhang, X., Shakeel, M., Salim, A., Wan, H.*, Li, J., 2017. Sublethal effects of buprofezin on development and reproduction in the white-backed planthopper, Sogatella furcifera (Hemiptera: Delphacidae). Sci. Rep. 7, 16913.
25. Zhang, Y., Ji, J., Zhao, X., Jin, R., Li, J., Wan, H.*, 2017. Expression, purification and enzymatic properties of a β-N-acetylhexosaminidase from brown planthopper, Nilaparvata lugens. J. Asia-Pac. Entomol. 20, 1340-1343.
26. Liao, X., Mao, K., Ali, E., Zhang, X., Wan, H.*, Li, J., 2017. Temporal variability and resistance correlation of sulfoxaflor susceptibility among Chinese populations of the brown planthopper Nilaparvata lugens (Stål). Crop Prot. 102, 141-146.
27. Zhang, X. #, Liao, X. #, Mao, K., Yang, P., Li, D., Ali, E., Wan, H., Li, J., 2017. Neonicotinoid insecticide resistance in the field populations of Sogatella furcifera (Horváth) in Central China from 2011 to 2015. J. Asia-Pac. Entomol. 20, 955-958.
28. Chen, Z.S., Han, N.N., Li, J.H., Huang, G.H., Wan, H.*, 2017. Selection of reference genes for expression analysis using RT-qPCR in the dissemination system of Heliothis virescens ascovirus 3 h (HvAV-3h). Sci. Rep. 7, 7045.
29. Shen, J., Li, D., Zhang, S., Zhu, X., Wan, H., Li, J., 2017. Fitness and inheritance of metaflumizone resistance in Plutella xylostella. Pestic. Biochem. Physiol. 139, 53-59.
30. Zhang, S. #, Zhang, X. #, Shen, J., Li, D., Wan, H., You, H., Li, J., 2017. Cross-resistance and biochemical mechanisms of resistance to indoxacarb in the diamondback moth, Plutella xylostella. Pestic. Biochem. Physiol. 140, 85-89.
31. Kang, T., Jin, R., Zhang, Y., Wan, H., Lee, K.S., Jin, B.R.*, Li, J.*, 2017. Functional characterization of the aspartic proteinase cathepsin D in the beet armyworm (Spodoptera exigua). Gene 617, 1-7.
32. Chen, Z.S., Han, N.N., Li, J.H., Wan, H., Huang, G.H.*, 2017. Selection and validation of reference genes for RT-qPCR analysis in Sf9 cell line infected by Heliothis virescens ascovirus 3h (HvAV-3h). J. Asia-Pac. Entomol. 20, 463-468.
33. Salim, A., Shakeel, M., Ji, J., Kang, T., Zhang, Y., Ali, E., Zhao, X., Lu, Y.*, Wan, H.*, Li, J., 2017. Cloning, expression, and functional analysis of two acetylcholinesterase genes in Spodoptera litura (Lepidoptera: Noctuidae). Comp. Biochem. Physiol. B. 206, 16-25.
34. Zhang, X., Liao, X., Mao, K., Yang, P., Li, D., Alia, E., Wan, H.*, Li, J., 2017. The role of detoxifying enzymes in field-evolved resistance to nitenpyram in the brown planthopper Nilaparvata lugens in China. Crop Prot. 94, 106-114.
35. 张小磊，廖逊，毛凯凯，李建洪，万虎*，2016. 湖北稻区白背飞虱田间种群抗药性监测. 昆虫学报. 59, 1213-1221.
36. Liu, S., Xie, J., Cheng, J., Li, B., Chen, T., Fu, Y., Li, G., Wang, M., Jin, H., Wan, H., Jiang, D., 2016. Fungal DNA virus infects a mycophagous insect and utilizes it as a transmission vector. PNAS. 113, 12803-12808.
37. Xu, P., Han, N., Kang, T., Zhan, S., Lee, K.S., Jin, B.R., Li, J., Wan, H.*, 2016. SeGSTo, a novel glutathione S-transferase from the beet armyworm (Spodoptera exigua) involved in detoxification and oxidative stress. Cell Stress Chaperones. 21, 805-816.
38. Zhang, X., Liao, X., Mao, K., Zhang, K., Wan, H.*, Li, J.*, 2016. Insecticide resistance monitoring and correlation analysis of insecticides in field populations of the brown planthopper Nilaparvata lugens (stål) in China 2012–2014. Pestic. Biochem. Physiol. 132, 13-20.
39. Wan, H., Zhan, S., Xia, X., Xu, P., You, H., Jin, B.R.*, Li, J.*, 2016. Identification and functional characterization of an epsilon glutathione S-transferase from the beet armyworm (Spodoptera exigua). Pestic. Biochem. Physiol. 132, 81-88.
40. Zhang, Y., Zhao, X., Ji, J., Kang, T., Li, J., Wan, H.*, 2016. Molecular cloning and characterization of a phenylalanine hydroxylase from the common cutworm Spodoptera litura. J. Asia-Pac. Entomol. 19, 365-370.
41. Wan, H., Zhang, Y., Zhao, X., Ji, J., You, H., Li, J.*, 2015. Enhancing the insecticidal activity of recombinant baculovirus by expressing a growth-blocking peptide from the beet armyworm Spodoptera exigua. J. Asia-Pac. Entomol. 18, 535-539.
42. Shakeel, M., Zhu, X., Kang, T., Wan, H., Li, J.*, 2015. Selection and evaluation of reference genes for quantitative gene expression studies in cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae). J. Asia-Pac. Entomol. 18, 123-130.
43. Kang, T. #, Wan, H. #, Zhang, Y., Shakeel, M., Lu, Y., You, H., Lee, K.S., Jin, B.R.*, Li, J.*, 2015. Comparative study of two thioredoxins from common cutworm (Spodoptera litura): cloning, expression, and functional characterization. Comp. Biochem. Physiol. B. 182, 47-54.)
44. Wan, H., Kang, T., Kim, B.Y., Lee, K.S., Li, J., Jin, B.R.*, 2015. AvCystatin, a novel cysteine protease inhibitor from spider (Araneus ventricosus) venom. J. Asia-Pac. Entomol. 18, 13-18.
45. Wan, H. #, Kang, T. #, Zhan, S., You, H., Zhu, F., Lee, K.S., Zhao, H., Jin, B.R.*, Li, J.*, 2014. Peroxiredoxin 5 from common cutworm (Spodoptera litura) acts as a potent antioxidant enzyme. Comp. Biochem. Physiol. B. 175, 53-61.
46. Yuan, M., Lu, Y., Zhu, X., Wan, H., Shakeel, M., Zhan, S., Jin B.R., Li, J.*, 2014. Selection and Evaluation of Potential Reference Genes for Gene Expression Analysis in the Brown Planthopper, Nilaparvata lugens (Hemiptera: Delphacidae) Using Reverse-Transcription Quantitative PCR. PLoS One. 9, e86503.
47. Zou, F.M., Lee, K.S., Wan, H., Gui, Z.Z., Jin, B.R.*, 2014. Morphological abnormalities and lethality in silkworm (Bombyx mori) larvae treated with high concentrations of insect growth-blocking peptide. J. Asia-Pac. Entomol. 17, 93-97.
48. Wan, H. #, Kim, B.Y. #, Lee, K.S., Yoon, H.J., Lee, K.Y., Jin, B.R.*, 2014. A bumblebee (Bombus ignitus) venom serine protease inhibitor that acts as a microbial serine protease inhibitor. Comp. Biochem. Physiol. B. 167, 59-64. (Co-first author)
49. Kim, B.Y., Lee, K.S., Zou, F.M., Wan, H., Choi, Y.S., Yoon, H.J., Kwon, H.W., Je, Y.H., Jin, B.R.*, 2013. Antimicrobial activity of a honeybee (Apis cerana) venom Kazal-type serine protease inhibitor. Toxicon 76, 110-117.
50. Wan, H., Lee, K.S., Kim, B.Y., Yuan, M., Zhan, S., Lu, Y., You, H., Li, J.*, Jin, B.R.*, 2013. Developmental regulation and antifungal activity of a growth-blocking peptide from the beet armyworm Spodoptera exigua. Dev. Comp. Immunol. 41, 240-247.
51. Lu, Y., Yuan, M., Gao, X., Kang, T., Zhan, S., Wan, H., Li, J.*, 2013. Identification and validation of reference genes for gene expression analysis using quantitative PCR in Spodoptera litura (Lepidoptera: Noctuidae). PLoS ONE 8, e68059.
52. Wan, H., Lee, K.S., Kim, B.Y., Yuan, M., Zhan, S., You, H., Li, J.*, Jin, B.R.*, 2013. A spider (Araneus ventricosus) chymotrypsin inhibitor that acts as an elastase inhibitor and a microbial serine protease inhibitor. Comp. Biochem. Physiol. B. 165, 36-41.
53. Wan, H., Lee, K.S., Kim, B.Y., Zou, F.M., Yoon, H.J., Je, Y.H., Li, J., Jin, B.R.*, 2013. A spider-derived Kunitz-type serine protease inhibitor that acts as a plasmin inhibitor and an elastase inhibitor. PLoS ONE 8, e53343.
54. Wan, H., Lee, K.S., Choo, Y.M., Je, Y.H., Li, J., Jin, B.R.*, 2013. Molecular cloning and characterization of two peptide toxins from the spider Araneus ventricosus. J. Asia-Pac. Entomol. 16, 81-86.
55. Kim, B.Y., Lee, K.S., Wan, H., Zou, F.M., Choi, Y.S., Yoon, H.J., Kwon, H.W., Je, Y.H., Jin, B.R.*, 2013. Anti-elastolytic activity of a honeybee (Apis cerana) chymotrypsin inhibitor. Biochem. Biophys. Res. Commun. 430, 144-149.
56. Wan, H., Yuan, M., You, H., Li, J.*, Jin, B.R.*, 2012 Molecular cloning and characterization of a diapause-specific peptide in the beet armyworm, Spodoptera exigua. J. Asia-Pac. Entomol. 15, 369-373.
57. Choo, Y.M., Lee, K.S., Yoon, H.J., Qiu, Y., Wan, H., Sohn, M.R., Sohn, H.D., Jin, B.R.*, 2012. Antifibrinolytic role of a bee venom serine protease inhibitor that acts as a plasmin inhibitor. PLoS ONE 7, e32269.
58. Kim, B.Y., Hui, W.L., Lee, K.S., Wan, H., Yoon, H.J., Gui, Z.Z., Chen, S., Jin, B.R.*, 2011. Molecular cloning and oxidative stress response of a sigma-class glutathione S-transferase of the bumblebee Bombus ignitus. Comp. Biochem. Physiol. B. 158, 83-89.
59. You, H. #, Wan, H. #, Li, J., Jin, B.R.*, 2010. Molecular cloning and characterization of a short peptidoglycan recognition protein (PGRP-S) with antibacterial activity from the bumblebee Bombus ignitus. Dev. Comp. Immunol. 34, 977-985.
