张静柏，女，1979年生，博士，新葡萄官网登录入口新葡萄官网登录入口教师。1998-2002年就读于于河北农业大学植物保护专业，2002-2008年就读于新葡萄官网登录入口攻读植物病理学专业博士学位，2008年1月获农学博士学位，毕业留校任教，承担《农业植物病理学》、《农业植物病理学实验》、《植物病害流行学》、《园林植物病理学》等课程教学。2017年6月-2018年6月在美国麻省大学阿默斯特分校进行访学研究。从事赤霉菌分子生物学、赤霉菌及其毒素特异抗体分离与毒素分析检测、小麦抗赤霉菌及毒素分子育种等方面研究，主持相关国家自然基金青年科学基金、教育部高等学校博士学科点专项新教师基金、武汉市科技攻关计划项目各1项，曾作为主要参与者完成国家“973”、“中德国际合作重点项目”多个国家课题，现作为骨干力量参加国家重大科技专项-转基因新品种培育1项、国家重点研发计划项目1项，共计发表研究论文40余篇（SCI论文30余篇），授权或申请专利15项，其中国际专利1项。

1. 横向项目，湖北省小麦赤霉病菌毒素检测及新型抗病资源的开发，项目年限：2018-2020，（主持）

2. 科技部，国家重点研发计划，湖北麦区小麦化肥农药增效减施技术集成研究与示范，项目年限：2018-2020，（参加）

3. 科技部，国家重大科技专项，抗赤霉病转基因小麦新品系培育，项目年限：2016-2020，（参加）

4. 农业部，国家科技重大专项转基因生物新品种培育项目，高抗赤霉病和毒素转基因小麦新品种培育，项目年限：2014-2016，（参加）

5. 国家自然科学基金青年科学基金项目，赤霉菌致病相关基因CR1 的鉴定和功能分析，项目年限：2013-2015，（主持）

6. 武汉市科技局，武汉市科技计划项目，抗伏马菌素特异重组抗体的分离及应用，项目年限：2013-2014，（主持）

7. 国家自然科学基金面上项目，抗病抗体识别的赤霉病菌表面抗原基因克隆与功能鉴定，项目年限：2013-2016，（参加）

8. 农业部，转基因重大专项，抗赤霉病转基因小麦新品系和新种质创制，项目年限：2011-2015，（参加）

9. 教育部，新教师基金，我国长江中下游小麦、玉米赤霉菌系统群及产毒性比较研究，项目年限：2009-2012，（主持）

部分发明专利：

1. 廖玉才，何伟杰，李和平，易沭远，张静柏，黄涛. 镰刀菌毒素脱毒路径相关基因ADH、AKR6D1、AKR13B2及其应用. 授权日：2020.08.11

2. Liao, Y.-C., Li, H.-P., Zhang, J.-B., Huang, T., Song, X.-S., Cheng, W., Yang, P. Fusarium chitin synthase gene Chs3b and the use thereof. 授权日：2019.07.16

3. 廖玉才，李和平，张静柏，杨鹏. 一种禾谷镰刀菌葡聚糖合成酶基因GLS及应用. 授权日：2019.12.13

4. 廖玉才；宫安东；李和平；张静柏. 防治作物储藏期黄曲霉菌及毒素的海藻希瓦氏菌及其应用. 授权日：2018.04.10

5. 廖玉才，宫安东，李和平，张静柏. 一株防治小麦赤霉病的解淀粉芽孢杆菌及其应用. 授权日：2017.08.15

6. 廖玉才，李和平，胡祖权，张静柏. 抗伏马菌素B1的单克隆重组抗体H2.授权日：2015.01.28

7. 廖玉才，李和平，胡祖权，张静柏. 抗伏马菌素B1的单克隆重组抗体H7. 授权日：2015.01.28

8. 廖玉才，胡祖权，李和平，张静柏. 镰刀菌特异单链抗体及制备方法和应用.授权日：2014.09.10

9. 廖玉才，王建华，李和平，张静柏，黄涛. 一种镰刀菌单端孢霉烯族A类毒素的分子鉴定方法. 授权日：2014.06.18

10. 廖玉才，王建华，李和平，张静柏，黄涛，瞿波. 玉米赤霉烯酮毒素的分子检测方法及应用. 授权日：2014.04.02

主要奖励：

2014年获得新葡萄官网登录入口教学质量三等奖

学术论文

第一作者或通讯作者文章

1. Yang, P., Yi, S.-Y., Nian, J.-N., Yuan, Q.-S., He, W.-J., Zhang, J.-B*., Liao, Y.-C*. Application of double-strand RNAs targeting chitin synthase, glucan synthase, and protein Kinase reduces Fusarium graminearum spreading in wheat. Frontiers in Microbiology, 2021, 12: 660976.

2. He, W.-J., Shi, M.-M., Yang, P., Huang, T., Zhao, Y., Wu, A.-B., Dong, W.-B., Li, H.-P., Zhang, J.-B*., Liao, Y.-C*. A quinone-dependent dehydrogenase and two NADPH-dependent aldo/keto reductases detoxify deoxynivalenol in wheat via epimerization in a Devosia strain. Food Chemistry, 2020, 321: 126703.

3. He, W.-J., Shi, M.-M., Yang, P., Huang, T., Yuan, Q.-S., Yi, S.-Y., Wu, A.-B., Li H.-P., Gao C.-B., Zhang J.-B*., Liao Y.-C*. Novel soil bacterium strain Desulfitobacterium sp. PGC-3-9 detoxifies trichothecene mycotoxins in wheat via de-epoxidation under aerobic and anaerobic conditions. Toxins, 2020, 12(6): 363.

4. Gong, A.-D., Sun, G.-J., Zhao, Z.-Y., Liao, Y.-C., Zhang, J.-B*. Staphylococcus saprophyticus L-38 produces volatile, 3-dimethyl-1,2-epoxybutane with strong inhibitory activity against Aspergillus flavus germination and aflatoxin production. World Mycotoxin Journal, 2020: 13 (2): 247-258.

5. Hu, Z.-Q., Li, H.-P., Liu, J.-L., Xue, S., Gong, A.-D., Zhang, J.-B*., Liao, Y.-C. Production of a phage-displayed mouse scFv antibody against Fumonisin B1 and molecular docking analysis of their interactions. Biotechnology and Bioprocess Engineering, 2016, 21: 134-143.

6. Wang, J.-H. #, Zhang, J.-B.#, Li, H.-P., Gong, A.-D., Liao, Y.-C. Molecular identification, mycotoxin production and comparative pathogenicity of Fusarium temperatum isolated from maize in China . Journal of Phytopathology, 2014, 162: 147-157.（共同第一作者）

7. Zhang, J.-B., Wang, J.-H., Gong, A.-D., Chen, F.-F., Song, B., Li, H.-P., Li, X., Peng, C.-H., Liao Y.-C*. Natural occurrence of Fusarium head blight, mycotoxins, and mycotoxin-producing strains of Fusarium in commercial fields of wheat in Hubei. Plant Pathology, 2013, 62: 92-102.

8. Li, X.#, Zhang, J.-B.#, Song, B., Li, H.-P., Xu, H. Q., Qu, B., Dang, F.-J., Liao, Y.-C*. Resistance to Fusarium head blight and seedling blight in wheat is associated with activation of a cytochrome P450 gene. Phytopathology, 2010, 100:183-191.

9. Li, H.-P. #, Zhang, J.-B.#, Shi, R.-P., Huang, T., Fischer, R., Liao, Y.-C. Engineering Fusarium head blight resistance in wheat by expression of a fusion protein containing a Fusarium-specific antibody and an antifungal peptide. Molecular Plant-Microbe Interaction, 2008, 21:1242-1248.

10. Zhang, J.-B., Li, H.-P., Dang, F.-J., Qu, B., Xu, Y.-B., Zhao, C.-S., Liao, Y.-C. Determination of the trichothecene mycotoxin chemotypes and associated geographical distribution and phylogenetic species of the Fusarium graminearum clade from China. Mycological Research, 2007, 111:967-975.

11. 胡祖权，李和平，刘锦龙，吴平，廖玉才，张静柏*. 抗伏马菌素B1单克隆重组抗体的筛选. 基因组学与应用生物学，2015，34(9)：1912-1916

12. 胡祖权，李和平，吴平，廖玉才，张静柏*. 抗镰刀菌单链抗体在大肠杆菌中可溶性表达条件的研究. 生物技术通报，2015，31(9)：238-243

其他作者英文文章

1. Wang, L., Yan Z., Zhou H.-Y., Fan Y.-Y., Wang C., Zhang, J.-B., Liao, Y.-C., Wu, A.-B. Validation of LC-MS/MS coupled with a chiral column for the determination of 3- or 15-acetyl deoxynivalenol mycotoxins from Fusarium graminearum in wheat. Toxins, 2021, 13(9): 659.

2. Guo, M.-W., Yang, P., Zhang, J.-B., Liu, G., Yuan, Q.-S, He, W.-J., Nian, J.-N., Yi, S.-Y, Huang, T., Liao, Y.-C. Expression of microRNA-like RNA-2 (Fgmil-2) and bioH1 from a single transcript in Fusarium graminearum are inversely correlated to regulate biotin synthesis during vegetative growth and host infection, Molecular Plant Pathology, 2019, 20(11): 1574-1581.

3. Song, X.-S., Xing, S., Li, H.-P., Zhang, J.-B., Qu, B., Jiang, J.-H., Fan, C., Yang, P., Liu, J.-L., Hu, Z.-Q., Xue, S., Liao, Y.-C*. An antibody that confers plant disease resistance targets a membrane-bound glyoxal oxidase in Fusarium. New Phytologist, 2016, 210(3): 997-1010.

4. He, W.-J., Yuan, Q.-S, Zhang, Y.-B., Guo, M.-W., Gong, A,-D., Zhang, J.-B., Wu, A.-B., Huang, T., Qu, B., Li, H.-P., Liao, Y.-C. Aerobic de-Epoxydation of trichothecene mycotoxins by a soil bacterial consortium isolated using in situ soil enrichment. Toxins, 2016, 8, 277.

5. Cheng, W., Song, X.-S., Li, H.-P., Cao, L.-H., Sun, K., Qiu, X.-L., Xu, Y.-B., Yang, P., Huang, T., Zhang, J.-B., Qu, B., Liao, Y.-C. Host-induced gene silencing of an essential chitin synthase gene confers durable resistance to Fusarium head blight and seedling blight in wheat. Plant Biotechnology Journal, 2015, 13, 1335-1345.

6. Cheng, W., Li, H.-P., Zhang, J.-B., Du, H.-J., Wei, Q.-Y., Huang, T., Yang, P., Kong, X.-W., Liao, Y.-C. Tissue-specific and pathogen-inducible expression of a fusion protein containing a Fusarium-specific antibody and a fungal chitinase protects wheat against Fusarium pathogens and mycotoxins. Plant Biotechnology Journal, 2015, 13: 664-674.

7. Gong, A,-D., Li, H.-P., Shen, L., Zhang, J.-B., Wu, A.-B., He, W.-J., Yuan, Q.-S., He, J.-D., Liao, Y.-C. The Shewanella algae strain YM8 produces volatiles with strong inhibition activity against Aspergillus pathogens and aflatoxins. Frontiers in Microbiology, 2015, Oct 6. doi: 10.3389/fmicb.2015.01091.

8. Hu, Z.-Q., Li, H.-P., Wu, P., Li, Y.-B., Zhou, Z.-Q., Zhang, J.-B., Liu, J.-L., Liao, Y.-C*. An affinity improved single-chain antibody from phage display of a library derived from monoclonal antibodies detects fumonisins by immunoassay. Analytica Chimica Acta, 2015, 867: 74-82.

9. Gong, A.-D., Li, H.-P., Yuan, Q.-S., Song, X.-S., Yao, W., He, W.-J., Zhang, J.-B., Liao, Y.-C. Antagonistic mechanism of iturin A and plipastatin A from Bacillus amyloliquefaciens S76-3 from wheat spikes against Fusarium graminearum. PLoS ONE, 2015 Feb 17;10(2): e0116871.

10. Song, X.-S., Li, H.-P., Zhang, J.-B., Song, B., Huang, T., Du, X.-M., Gong, A.-D., Liu, Y.-K., Feng, Y.-N., Agboola, R.S., Liao, Y.-C. Trehalose 6-phosphate phosphatase is required for development, virulence and mycotoxin biosynthesis apart from trehalose biosynthesis in Fusarium graminearum. Fungal Genetics and Biology, 2014, 63: 24-41.

11. Wang, J.-H., Li, H.-P., Zhang, J.-B., Wang, B.-T., Liao, Y.-C. First report of Fusarium maize ear rot caused by Fusarium kyushuense in China . Plant Disease, 2014, 98: 279-280. DOI: 10.1094/PDIS-05-13-0558-PDN.

12. Xue, S., Li, H.-P., Zhang, J.-B., Liu, J.-L., Hu, Z.-Q., Gong, A.-D., Huang, T., Liao, Y.-C. Chicken single-chain antibody fused to alkaline phosphatase detects Aspergillus pathogens and their presence in natural samples by direct sandwich enzyme-linked immunosorbent assay. Analytical Chemistry, 2013, 85, 10992-10999.

13. Song, B., Li, H.-P., Zhang, J.-B., Wang, J.-H., Gong, A.-D., Song, X.-S., Chen T., Liao, Y.-C. Type II myosin gene in Fusarium graminearum is required for septation, development, mycotoxin biosynthesis and pathogenicity. Fungal Genetics and Biology, 2013, 54: 60-70.

14. Hu, Z.-Q., Li, H.-P., Zhang, J.-B., Huang, T., Liu, J.-L., Xue, S., Wu, A.-B., Liao, Y.-C. A phage-displayed chicken single-chain antibody fused to alkaline phosphatase detects Fusarium pathogens and their presence in cereal grains. Analytica Chimica Acta, 2013, 764: 84-92.

15. Gao, C.-S., Kou, X.-J., Li, H.-P., Zhang, J.-B., Saad, A. Sefyan I., Liao, Y.-C. Inverse effects of Arabidopsis NPR1 gene on fusarium seedling blight and fusarium head blight in transgenic wheat. Plant Pathology, 2013, 62: 383-392.

16. Liu, Z.-W., Li, H.-P., Cheng, W., Yang, P., Zhang, J.-B., Gong, A.-D., Feng, Y.-N., Fernando, W. G. D., Liao, Y.-C. Enhanced overall resistance to Fusarium seedling blight and Fusarium head blight in transgenic wheat by co-expression of anti-fungal peptides. European Journal of Plant Pathology, 2012, 134: 721-732.

17. Hu, Z.-Q., Liu, J. L., Li, H.-P., Xing, S., Xue, S., Zhang, J.-B., Wang, J.-H., Nölke, G., Liao, Y.-C. Generation of a highly reactive chicken-derived single-chain variable fragment against Fusarium verticillioides by phage display. International Journal of Molecular Sciences,2012, 13, 7038-7056.

18. Ndoye, M., Zhang, J-B., Wang, J.-H., Gong, A.-D, Qu, B., Li, H.-P., Li, S.-J, Liao, Y.-C. Nivalenol and 15-acetyldeoxynivalenol chemotypes of Fusarium graminearum clade species are prevalent on maize throughout China . Journal of Phytopathology, 2012, 160: 519-524.

19. Wang, J.-H., Zhang, J-B., Chen, F.- F., Li, H.-P., Ndoye M., Liao, Y.-C. A multiplex PCR assay for genetic chemotyping of toxigenic Fusarium graminearum and wheat grains for 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol and nivalenol mycotoxins. Journal of Food, Agriculture and Environment. 2012, 10: 505-511.

20. Liu, J.-L., Hu, Z.-Q., Xing, S., Xue, S., Li, H.-P., Zhang, J.-B., Liao, Y.-C. Attainment of 15-fold higher affinity of a Fusarium-specific single-chain antibody by directed molecular evolution coupled to phage display. Molecular Biotechnology, 2012, 52: 111-122.

21. Liu, G., Han, Z., Nie, D., Yang, J., Zhao, Z. H., Zhang, J. B., Li, H.P., Liao, Y. C., Song, S., Saeger, S. D., Wu, A. B. Rapid and sensitive quantitation of zearalenone in food and feed by lateral flow immunoassay. Food Control, 2012, 27: 200-205.

22. Han, Z., Zhao, Z.-Y., Song, S.-Q., Liu, G., Shi, J.-X., Zhang, J.-B., Liao, Y.-C., Zhang, D.-B., Saeger, S. D., Wu, A.-B. Establishment of a model isotope dilution LC-MS/MS method revealing kinetics and distribution of co-occurring mycotoxins in rat. Analytical Methods, 2012, 4, 3708–3717.

23. Wang, J.-H., Ndoye, M., Zhang, J.-B., Li, H.-P., Liao, Y.-C. Population structure and genetic diversity of the Fusarium graminearum species complex. Toxins, 2011, 3, 1020-1037.

24. 宫安东，孔宪巍，翟新可，路亚南，文淑婷，张静柏. 枯草芽胞杆菌WY8-7的溶磷、抑菌及促生长作用. 南京农业大学学报，2019，42（4）：697-705

25. 何伟杰，刘易科，朱展望，张静柏，高春保，廖玉才. 镰刀菌毒素脱氧雪腐镰刀菌烯醇脱毒菌及脱毒酶研究进展. 植物病理学报，2019，49（5）：577-589

26. 胡祖权，李和平，张静柏，刘锦龙，廖玉才. 伏马菌素B1特异单链抗体的同源建模及分子对接模拟研究. 免疫学杂志，2015，31（7）：618-622

教材与著作

1. 《普通遗传学实验》参编，2015，高等教育出版社

2. 《遗传学》（第三版），参编，2015，科学出版社

3. 《植物生物技术》（第二版），参编，2012，科学出版社